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Cytomegalovirus DNAemia and risk of mortality in allogeneic hematopoietic stem cell transplantation: Analysis from the Spanish Hematopoietic Transpla…

2020

The net impact of cytomegalovirus (CMV) DNAemia on overall mortality (OM) and nonrelapse mortality (NRM) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a matter of debate. This was a retrospective, multicenter, noninterventional study finally including 749 patients. CMV DNA monitoring was conducted by real-time polymerase chain reaction (PCR) assays. Clinical outcomes of interest were OM and NRM through day 365 after allo-HSCT. The cumulative incidence of CMV DNAemia in this cohort was 52.6%. A total of 306 out of 382 patients with CMV DNAemia received preemptive antiviral therapy (PET). PET use for CMV DNAemia, but not the occurrence of CMV DNAemia, taken …

Oncologymedicine.medical_specialtybone marrowinfection and infectious agents - viralmedicine.medical_treatmentCongenital cytomegalovirus infectionCytomegaloviruscomplicationHematopoietic stem cell transplantation030230 surgerylaw.inventionCell therapy03 medical and health sciences0302 clinical medicinelawInternal medicinehemic and lymphatic diseasesRisk of mortalityImmunology and AllergyMedicineHumansTransplantation HomologousPharmacology (medical)Cumulative incidencePolymerase chain reactionRetrospective StudiesTransplantationbusiness.industryHematopoietic Stem Cell Transplantationvirus diseasesmedicine.diseasepracticeTransplantationinfectious infection and infectious agents - viral: Cytomegalovirus (CMV) [bone marrow/hematopoietic stem cell transplantation clinical research/practice complication]infectiousclinical researchCohortCytomegalovirus InfectionsDNA Viralhematopoietic stem cell transplantationCytomegalovirus (CMV)business
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